Word on the street is that the book shown below, by Jennifer Doudna and Samuel Sternberg, is very good (it’s out on June 13; click on screenshot to go to Amazon link). You may have heard of Berkeley professor Jennifer Doudna, one of the pioneers in using the new CRISPR technique to genetically edit cells—”genome editing”; co-author Samuel Sternberg studied with Doudna as a postdoc and now works for a biotechnology company.
And I hope you’ve heard of CRISPR (“clustered regularly interspaced short palindromic repeats”), which is a method of genome editing that grew out of pure science: the discovery that bacteria have immune systems in which they incorporate into their own DNA short bits of DNA from invading viruses, and then use those bits, along with an enzyme called Cas9, to cut up and destroy the genomes of those viruses when they invade again. This is analogous to our own immune system, which has a memory that can inactivate harmful proteins the body has experienced before. (This is the basis of vaccination.) That pure science grew, through the work and ingenuity of many scientists, into a method that now enables us to cut DNA at any given sequence in nearly any species (including our own), and then insert new DNA of our own making, or DNA taken from other cells. We could cure sickle-cell anemia by editing into sufferers the “normal” hemoglobin gene, and do likewise with many other genetic diseases. We could get rid of the AIDS virus that hides in the human genome. We could genetically engineer crops to make them resistant to insects and herbicides. We can study gene function by selectively inactivating genes or visualizing their expression using proteins that fluoresce. We already have some ability to do these things, but the CRISPR-Cas9 system makes this dead easy.
But there’s also the possibility of editing not just the genes in bodies, but the genes in sperm and eggs, giving rise to the possibility of genetically changing our own and other species, permanently—or directing our own evolution. (It’s not just humans, either; we could alter disease-carrying insects to render them harmless.) The possibility of germline editing carries with it severe ethical problems: how much can we and should we change our own genetic legacy? Both the methodology and ethics are discussed in Doudna and Sternberg’s book, as this Amazon summary shows:
A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.
Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?

(There’s some nastiness in the field about who gets priority for this discovery, as it’s sure to garner a Nobel Prize (getting CRISPR to this point is the work of dozens of people, but certain scientists—not Doudna or Sternberg—are trying to establish hegemony. There’s also a big patent battle over the use of the system, but I won’t get into that. Go here if you want to read the dirty details.)
Now you could read about the CRISPR-Cas9 system on Wikipedia, or you could read a good but technical paper by Doudna and Emmanuelle Charpentier (another pioneer in this area) published in Science (free at the link). But if you have any interest in science, or in bioethics, I’d strongly urge you to learn about the new methods of gene editing, how they work, what they can do, and their ethical implications. You might order the book above, and I’d also direct you to two explanations by our own Matthew Cobb.
The first is a BBC show he did about gene editing, (“Editing life”), whose description and link I’ve given before.
And now Matthew’s just published a short primer on the issue called “The brave new world of CRISPR”, which appeared in the new Biological Sciences Review. That piece will bring every reader up to speed. Sadly, it’s not online free, but if you email me I’ll send you a pdf.
The CRISPR system is the most important innovation in biotechnology since the advent of DNA sequencing methods; its development is a fascinating story and its ethical implications are profound. You need to learn about it if you have any interest in science. I’ve given you at least five resources to do so.
Here are Doudna and Sternberg:
