A radio programme about gene editing

February 8, 2016 • 1:03 pm

by Matthew Cobb

I’ve recently made a BBC radio programme about gene editing, a new form of genetic manipulation that generally goes by the name of the acronym CRISPR. Over the last 3-4 years this technique has taken biological and medical research by storm. Clinical trials of therapies for patients suffering blood-born genetic diseases may be only a couple of years away. Although the prospect of ‘designer babies’ excite ethicists and the media, I think a bigger issue is posed by the prospect of CRISPR-based ‘gene drives’.

Gene drives are techniques for spreading genes through a sexually-reproducing population, which can very quickly affect every organism. These are the approaches that some people are suggesting would be a way of stopping diseases transmitted by certain species of mosquito, by rendering all the mosquitoes sterile (and thereby making them disappear) or by altering them so that they cannot host the malaria parasite, or they cannot detect their human prey).

Clearly, things could go wrong, and we could find ourselves doing serious damage to the ecosystem. For the moment, there are no international regulations to control this kind of work, even though many of the scientists involved are keen to see such a framework.

In the radio programme, which only lasts 30 minutes, I explain how CRISPR works, talk to some of the people who developed CRISPR, and to those who are seeking to apply it, both in humans – there is a moving interview with the mother of a young boy with Duchenne’s Muscular Dystrophy, who founded a charity to support research – and in insects. The theme is the scientific, ethical and ecological implications of this amazing new technology.

The programme, which is called “Editing Life”, will be on BBC Radio 4 at 11:00 am UK time, tomorrow morning, Tuesday 9 February. There will also be an article in The Guardian, which I’ll link to tomorrow. In March there will be an extended version, consisting of two programmes, which will go out on the BBC World Service.

You can listen to the programme live here, from anywhere in the world. If you miss the programme, you can catch up with it here, again from anywhere in the world.

 

A real ceiling cat!

February 8, 2016 • 1:00 pm

The photo and notes below come from reader Judy:

Sasha has learned to walk on the screen cover of our patio. We are the staff of our resident ceiling cat. Please feel free to use this photo of her magnificence when you wish.
Sasha Ceiling Cat
And, with some judicious cropping, you can get this:
Sasha Ceiling Cat

How to photograph cats!

February 8, 2016 • 10:00 am

JAC: As I said, posting will be light this week, though Grania might start some discussion threads, and I expect people to PARTICIPATE! In the meantime, today is shaping up to be a cat-post day. I am in the small village of Denton, near Olney, visiting friends. Some spectacular wines on tap for dinner tonight.  Matthew, though, has contributed a post

by Matthew Cobb

From one of my favourite and most eclectic Tw*tter accounts, @PulpLibrarian.

Walter Chandoha has been taking photos of cats for 70 years! Aged 94 he is still snapping away, and has a website where you can buy copies of his cat photos (and others). He published a book of his cat photos in 2015, and was interviewed by Wired magazine, who described him as ‘the godfather of cat photographers’. [JAC: Walter’s daughter Paula was the official photographer of the Museum of Comparative Zoology at Harvard when I was a grad student, and she took some fine photos of gels for me.]

And now a word (or three) from our sponsor, Puss n Boots cat food:

Monday: Hili Dialogue

February 8, 2016 • 4:07 am

Good morning everyone; greetings from a miserably grey, rainy Ireland. Grania here again to post today’s Hili (and friends) as PCC(E) is otherwise occupied for now. Fortunately, we have a panoply of advice and deep thoughts from our four-footed cousins to help cheer us up for the working week.

Hili: Come on.
Cyrus: Just a moment, I can’t ascertain who was here.

P1030867

In Polish:

Hili: Chodź już.
Cyrus: Zaraz, nie mogę się zorientować, kto tu był.

And Leon is being very regal, if a little fanciful this morning. It suits his serious demeanor.

Leon: It’s me, Leon. Not any stupid princess on a pea.

leon princess

Reader Anne-Marie sent in a photograph of a squirrel.

Shakespeare once wrote: “The common curse of mankind, – folly and ignorance (…)”
And I would add “not feeding pet squirrels”.

sqrl

Reader Taskin sent in a picture of the beautiful Gus, with this advice to Jerry, who was waiting for his delayed flight.

Okay, so when they’re about to open the gate, Gus wants you to line up like this and then RUN!

gus

Now, onward and upwards!

 

 

 

I have landed

February 7, 2016 • 12:00 pm

It was a long and tiring flight to England. Not only was our plane more than two hours late in leaving Chicago, but we also had to wait for a half an hour once we landed until a gate became open. After that it becomes pure Heathrow Hell: the arrival hall at Heathrow’s international terminal (terminal 5) is a house of horrors, with only a handful of immigration agents servicing a horde of tired and antsy travelers. Hurry up and wait an hour! I still think Heathrow is the worst major airport I’ve ever visited.

On the other hand, I watched several good movies on the plane, including “Suffragette” with Carey Mulligan (well worth watching, Meryl Streep has a cameo), and “Everest“, recounting the 1996 mountain disaster described in Jon Krakauer’s bestseller Into Thin Air. (It’s a movie well worth watching if you like mountains and climbing; I loved seeing the Everest region again, my favorite place on Earth, even though the story is horrific and heartbreaking.) Out of curiosity, I also watched “Amy“, a documentary about the singer Amy Winehouse (by the way, she lived in Camden Square next door to my biologist friend Steve Jones, who used to complain bitterly about the paparazzi). Packed with clips from Winehouse’s life and a lot of her live performances, I found it fascinating and sad.  I knew little about Winehouse, but found her a terrific jazz singer. A great pity about the drugs. . .

And then on to Oggsford, where it cost 24 pounds to take the one-hour bus ride from Heathrow. That’s always the first indication that this country is, relative to the U.S., expensive. Average salaries are lower here, but transportation and food are either on par or even higher than U.S. prices. It’s a good thing there’s free medical care and good government services. I haven’t yet had my first pint, but I shudder to think what it costs these days. I’m guessing about four pounds.

Still, the medieval spires of Oxford glowed gold in the special sunlight that follows a morning thunderstorm, and it’s good to be here. I’ve had a proper cup of tea with ginger biscuits (“cookies” to us Yanks), a reminder that England still bests the U.S. in the biscuit department.  Among many, there are cow biscuits, Boasters, McVitie’s chocolate digestive biscuits, ginger biscuits studded with chunks of candied ginger, fig rolls, and my favorite: Garibaldis, also known as “squashed fly biscuits” (see below). For those who turn up their noses at the food here, read Orwell’s “In Defense of English Cooking.

I know what I’ll be looking for: good pub lunches, fish and chips, Indian food by Euston Station, and a big hunk of Keen’s Farmhouse Cheddar to take home.

garibaldi-biscuits-pile-traditional-english-isolated-white-background-44312409
Garibaldis, or “squashed fly” biscuits, a favorite of British drosophilists

Crawford_s_Garib_4c65e7df7f0ad