Carl Zimmer and Catrin Einhorn are the authors of a new article in the NYT about our old friend Colossal Biosciences, which you’ll remember as the outfit in Texas that has promised to “de-extinct” the woolly mammoth, the thylacine (marsupial “wolf”), the dodo and the moa, after having claimed that they’ve already de-extincted the “dire wolf”.
As I’ve written at length here (and in an article in the Boston Globe), Colossal has not de-extincted anything. It simply edited 14 genes in a gray wolf cell, and then put that cell into the nucleus of a domestic dog egg. What came out were three slightly tweaked gray wolves, white in color and, Colossal says, larger than normal wolves. But 14 changed genes in a genome of about 20,000 protein-coding genes, and having 2.5 billion DNA bases, does not turn a gray wolf into a dire wolf. Their response was that a dire wolf is anything that you think resembles a dire wolf, no matter how much. That is disingenuous.
I lost respect from Colossal when they decided to double down on their claim that they’ve brought something back from extinction, which they surely have not. And their claims that they will release these things into the wild—their ultimate aim—is ridiculous. The three faux white dire wolves (I doubt the original was even white) are kept secretly on an enclosure somewhere in the West, with only a few toadying journalists or donors allowed to visit them.
Likewise, Colossal’s promise to give us woolly mammoths by 2028 is unbelievable, for they won’t be able to put an engineered Asian elephant egg into the endangered Asian elephant, much less produce a creature that has more than a minute fraction of mammoth DNA. On top of that, Colossal says their aim is to release these faux mammoths on the tundra, which won’t happen, and that when they do so, it will help with global warming since the furry elephants’ trampling on the permafrost will prevent release of carbon dioxide into the atmosphere, ameliorating global warming. Gullible donors like Paris Hilton, Tiger Woods, and Tom Brady have swelled Colossal’s coffers by $400 million, and it’s now worth, notes the article below, more than $10 billion.
I think that when Colossal realized it couldn’t make good on its de-extinction promises, it started investing in other projects. One of them is described in this article in the NYT (click below or find it archived here). What they propose to do, with the promised help of the Trump administration, is save the DNA from endangered species. Now this project has its good aspects, for if Colossal sequences a lot of new genomes and publishes the sequences (which it promises to make public), we could learn quite a bit about evolution. And the American taxpayer doesn’t have to foot the bill for any of it. But Colossal has no experience in “biodiversity banking” of this sort, even though nonprofit conservation organizations like the San Diego Zoo Wildlife Alliance has been doing it for over half a century (Colossal is decidely a for-profit company). The San Diego noprofit has in fact created clones of black-footed ferrets, a highly endangered species, from biobanked material, so at least it has something useful to show for its efforts.
Further, if Colossal is doing this for “de-extinction” purposes, and will retain sole possession of the material, as it will do, then it is preventing other organizations or scientists from using what is “banked.” The U.S. government has no business partnering with such an enterprise. I don’t worry about de-extinction because that is (pardon the pun) a dead issue. But the concentration on biobanking may, as the authors note, “erode support for on-the-ground conservation,” which mainly involves saving existing habitat and keeping humans from destroying new habitat.
A few quotes from the article, which, as science journalism should, maintains a neutral viewpoint while emphasizing both pros and cons:
The Trump administration and a company that is promising to bring long-gone animals back from extinction announced a partnership on Thursday to preserve cells, tissue and DNA from threatened and endangered species.
The company, Colossal Biosciences, said its goal was to store samples from every animal and plant protected under the Endangered Species Act, which includes more than 2,300 listings worldwide.
As more species face the risk of extinction, scientists see such biobanks as a critical backup. But concerns are also growing that the rise of genetic engineering and efforts to revive extinct species will erode support for on-the-ground conservation, which often requires protecting habitat from drilling, mining and other development.
The announcement comes as the Trump administration has been rolling back protections on land and water, including through actions to weaken the Endangered Species Act, in favor of expanded oil and gas exploration, commercial fishing and other economic activities.
“This partnership brings together the scientific expertise of the U.S. Fish and Wildlife Service and the ingenuity of the private sector to develop new tools that can help recover species, preserve critical genetic resources, and strengthen the future of wildlife conservation,” Doug Burgum, the interior secretary, said in a statement.
Under a memorandum of understanding, Colossal and the Fish and Wildlife Service will collaborate to identify high-priority actions, and the government will provide a list of which species it wants to prioritize.
Well, I’d prefer that a consortium of scientists decide which species should be prioritized, and I’d prefer that the material be given to the San Diego Zoo organization rather than to Colossal, which will have sole use of the material and is a for-profit organization. The agreement is supposed to run for five years, and that Colossal gets to keep all the samples it collected with its own funding, equipment, or personnel”, which means pretty much all the samples.
Colossal has been busy doing other stuff, too:
After beginning its de-extinction efforts, Colossal branched out into biobanking. In February, the company announced a partnership with the United Arab Emirates to build what it calls a BioVault in Dubai, intended to store cell and tissue samples from more than 10,000 species.
Why Dubai? Why not store all the material in one place? Who knows? And they clone pets!
[Colossal] currently gets revenue from cloning pets and horses through a company it acquired last year, and claims to have future sources of revenue from licensing technology it develops for its de-extinction projects.
The article notes some criticism of Colossal’s proposal, too (I’m not quoting the criticism of the “de-extinction” endeavors, which the article also mentions):
But some conservation biologists expressed worries about depending so much for the long-term guardianship of precious samples on a private company.
“It seems like a bit of a risk for the U.S. government to place biomaterials in a for-profit company that doesn’t have a very long track record,” said Oliver Ryder, a conservation geneticist at the San Diego Zoo Wildlife Alliance, which operates a storage effort called the Frozen Zoo that has been preserving cells for about 50 years.
and
Gabriela Mastromonaco, chief science officer at the Toronto Zoo, called the U.S. plan laid out in Thursday’s announcement hugely ambitious.
“To collect every threatened and endangered species, that is a massive endeavor,” she said. “That means tracking, trapping, immobilizing, and getting your hands on a lot of animals.”
She expressed concern that the initial announcement was short on planning details that would be standard in many other nations.
. . . Dr. Mastromonaco of the Toronto Zoo said the announcement left many questions unanswered, such as how Indigenous communities would participate in decisions about the program and the rules for who gets to use the samples for research. She said she was addressing these questions herself as Canada develops its own plan for biobanking wild species.
and
Concerns that genetic engineering would replace critical conservation work heightened when Mr. Burgum, the interior secretary, celebrated the company’s announcement on X, writing that “the marvel of ‘de-extinction’ technology can help forge a future where populations are never at risk.” The Fish and Wildlife Service is part of the Interior Department.
Colossal executives emphasize that their efforts are intended to add to conservation strategies, not supplant the important work of protecting habitat.
I guess Colossal needs government cooperation since that’s required to collect DNA samples from endangered species. But if Colossal is dong this “for public good and impact” as Colossal CEO Ben Lamm has said, why do they retain the sole right to use the material? Even if it’s collected by Colossal, the permission to do so has to come from the U.S. government, and we should not be entangled with a private, for-profit company that will store material only it can use.
I see Colossal as having provided some valuable knowledge, but also largely as a pack of grifters, making promises they cannot keep and distorting what they have done. In my view they should stick to cloning Fido and Fluffy for rich pet-owners who want to “de-extinct” their postmortem pets.
h/t: Don
Egg-shaped frame: a lattice shell that gives the whole system its structure and protection.
Colossal membrane: the secret weapon. A bioengineered, gas-permeable layer that matches a real shell’s oxygen transfer, so O₂ flows in and CO₂ flows out exactly the way nature does it.
See-through build: the largely transparent design that lets us watch development in real time. This is critical for research and for de-extinction, where visually confirming milestones and the gene-edited traits we’ve put back is everything.
Modular scale: the platform will stretch to fit eggs of any size, including the South Island giant moa egg, roughly 80x the volume of a chicken egg.












