I saw this cat on Facebook, where she has her own page. Venus has apparently gone viral (see here, for instance) because of her “split face” appearance, which affects not only coat color and pattern, but eye color.
Now I could explain the genetics and developmental biology of the coat color, and why Venus would have to have been a female, but over at her website Planet of the Apes, Faye Flam has already done it, so go read her explanation. Note that Faye doesn’t explain the different eye colors, nor does National Geographic’s piece on Venus. Savvy readers may try their hand at this problem.
As for me, I don’t know why the eye colors are “split” along with the face. Eye color depends on genes different from those involved in coat color, so this may be a rare coincidence of somatic mutation (for eye color) that happens to accompany early inactivation of one X chromosome that carries coat color.
Venus’s Facebook page also has a diverse album of “split-face” cats and dogs.
h/t: Ant, Jon Losos, and many other readers who emailed me about Venus